For the treatment of moderate to severe hidradenitis suppurativa (HS) in patients 12 years of age and older

TARGETING TNF-α IN HS

Overexpression of cytokines, including TNF-α, plays a key role in fueling inflammation2,3

Moderate to severe HS is a chronic immune-mediated skin disease that can be progressive and debilitating.2,4-7

  1. Hair follicles become plugged with keratin, then rupture, leaking contents into connective tissue.3,8
  2. An inflammatory response follows, fueled by TNF-α and other proinflammatory cytokines, and an inflammatory nodule or abscess forms.2,3
  3. The wound heals, but the process becomes chronic, which may lead to sinus tracts and hypertrophic scars.8
HS in the axillae

MECHANISM OF ACTION IN HS

Explore how HUMIRA works to help target and block TNF-α in HS and disrupt the chronic cycle of inflammation.


MOA=mechanism of action; TNF-α=tumor necrosis factor alpha